Table 1. Network measures of clustered and homogeneous cultures.

Culture type	Network	DIV	burst rate (min)	Number of nodes	Number of edges	Average degree	Average strength	Assortativity Pearson (wh)	Assortativity Spearman (wh)
Clus.
	A	5	7.35	38	544	14.32	33.71	0.642 0.044	0.605 0.036
	B	6	6.80	34	1044	30.71	131.94	0.404 0.040	0.449 0.035
	C	6	6.55	29	762	26.28	142.45	0.440 0.036	0.425 0.041
	D	7	2.99	27	471	17.44	32.53	0.442 0.064	0.414 0.063
	E	7	0.87	29	660	22.76	22.83	0.402 0.043	0.396 0.045
	F	8	0.85	32	750	23.44	12.89	0.317 0.064	0.287 0.057
	G	8	0.79	35	395	11.29	4.99	0.528 0.086	0.553 0.063
	H	9	1.17	32	722	22.56	30.99	0.355 0.061	0.377 0.052
	I	10	3.19	27	486	18.00	81.88	0.460 0.046	0.478 0.046
	J	12	2.42	24	456	19.00	97.32	0.326 0.049	0.322 0.046
	K	13	1.28	19	252	13.26	38.27	0.729 0.062	0.699 0.051
	L	14	3.40	17	116	6.82	28.25	0.586 0.076	0.552 0.077
	M	14	1.40	25	205	8.20	16.71	0.356 0.084	0.309 0.087
	N	14	1.86	26	437	16.81	30.63	0.698 0.060	0.664 0.061
	O	14	4.91	29	391	13.48	38.77	0.372 0.069	0.364 0.061
Hom.
	P	6	3.30	814	453812	557.51	41.24	0.059 0.005	0.055 0.005
	Q	8	4.10	589	243606	413.59	27.66	0.038 0.007	0.036 0.007
	R	10	0.27	562	35379	62.95	2.46	0.112 0.023	0.125 0.023
	S	15	1.05	1107	239517	216.37	9.47	0.111 0.008	0.107 0.008
	T	16	0.47	694	274278	395.21	24.89	0.077 0.007	0.067 0.006
	U	16	0.78	703	155643	221.40	10.34	0.040 0.009	0.037 0.009

The table shows the major topological descriptors of the functional networks investigated, corresponding to a clustered neuronal organization and to a homogeneous one. Average degree refers to the mean number of connections per node, and the average strength to the mean weight per node. All the cultures were maintained and studied identically (see Methods). Experiments cover almost days of development in vitro (DIV). All clustered cultures are strongly assortative, while the homogeneous ones tend to be weakly assortative, or neutral.