Table 1. Neutralization titers against CHIKV-S27 and CHIKV-IND/NL10.
Animal # | Day 0 | Day 21 | Day 63 | Day 0 | Day 21 | Day 63 | Status after challenge |
MVA Vaccine | Challenge virus | ||||||
6KE1 | CHIKV-S27 | CHIKV-IND/NL10 | |||||
Mouse 1 | <10 | <10 | 10 | <10 | <10 | 20 | survived |
Mouse 2 | <10 | <10 | 20 | <10 | <10 | 20 | survived |
Mouse 3 | <10 | <10 | 10 | <10 | <10 | 10 | survived |
Mouse 4 | <10 | <10 | 10 | <10 | <10 | 10 | survived |
Mouse 5 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 6 | <10 | <10 | <10 | <10 | <10 | 10 | survived |
Mouse 7 | <10 | <10 | <10 | <10 | <10 | <10 | survived |
Mouse 8 | <10 | <10 | 10 | <10 | <10 | 10 | dead |
MVA Vaccine | Challenge virus | ||||||
E3E2 | CHIKV-S27 | CHIKV-IND/NL10 | |||||
Mouse 1 | <10 | 10 | 20 | <10 | 10 | 20 | survived |
Mouse 2 | <10 | <10 | 20 | <10 | 10 | 20 | survived |
Mouse 3 | <10 | <10 | 20 | <10 | 10 | 10 | survived |
Mouse 4 | <10 | <10 | 20 | <10 | 10 | 20 | survived |
Mouse 5 | <10 | 10 | 10 | <10 | 10 | 20 | survived |
Mouse 6 | <10 | 10 | 10 | <10 | 10 | 10 | survived |
Mouse 7 | <10 | <10 | 10 | <10 | <10 | 10 | survived |
Mouse 8 | <10 | 10 | 20 | <10 | 10 | 20 | survived |
MVA Vaccine | Challenge virus | ||||||
6KE1E3E2 | CHIKV-S27 | CHIKV-IND/NL10 | |||||
Mouse 1 | <10 | 10 | 80 | <10 | 20 | 80 | survived |
Mouse 2 | <10 | 10 | 80 | <10 | 10 | 80 | survived |
Mouse 3 | <10 | 10 | 160 | <10 | 20 | 160 | survived |
Mouse 4 | <10 | 10 | 80 | <10 | 10 | 80 | survived |
Mouse 5 | <10 | 20 | 40 | <10 | 20 | 80 | survived |
Mouse 6 | <10 | 10 | 40 | <10 | 20 | 40 | survived |
Mouse 7 | <10 | 20 | 80 | <10 | 20 | 160 | survived |
Mouse 8 | <10 | 20 | 40 | <10 | 20 | 40 | survived |
MVA Vaccine | Challenge virus | ||||||
Wildtype | CHIKV-S27 | CHIKV-IND/NL10 | |||||
Mouse 1 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 2 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 3 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 4 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 5 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 6 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 7 | <10 | <10 | <10 | <10 | <10 | <10 | dead |
Mouse 8 | <10 | <10 | <10 | <10 | <10 | <10 | dead |