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. 2014 Sep 4;8(9):e3145. doi: 10.1371/journal.pntd.0003145

Figure 3. Modeling the structure of B. malayi NMT and structural comparison with Leishmania major NMT.

Figure 3

(A) Ribbon diagram of the predicted crystal structure of NMT from B. malayi. (B) Comparison of B. malayi NMT (tan) with L. major NMT (blue: 2wsa). An overlay of the structure of these enzymes using UCSF Chimera [26] reveals a nearly identical conformation of the binding sites for myristoyl-CoA (yellow) and inhibitor DDD85646 (magenta). The 2 small helixes (arrow) formed by an insertion of 21 amino acids in L. major NMT are replaced with a loop in B. malayi NMT.