Table 1. Genetic association of the miRSNP-196a-2 and miRSNP-146a in the Rio de Janeiro sample: a case-control study of leprosy per se.
| SNP | Genotype/Allele | Case | Control | OR (95% CI; p Valor) | OR (95% CI; p Valor)* |
| miR-196a-2 (rs11614913) | CCb | 237 (0.48) | 272 (0.47) | - | - |
| CT | 203 (0.41) | 251 (0.44) | 0.93 (IC = 0.72–1.2; p = 0.5655) | 1.02 (IC = 0.71–1.46; p = 0.90) | |
| TT | 51 (0.1) | 52 (0.09) | 1.13 (IC = 0.74–1.72; p = 0.5841) | 1.18 (IC = 0.64–2.19; p = 0.59) | |
| Total | 491 | 575 | |||
| C-Alleleb | 677 (0.69) | 795 (0.69) | - | - | |
| T-Allele | 305 (0.31) | 355 (0.31) | 1.01 (IC = 0.78–1.31; p = 0.9468) | 1.06 (IC = 0.73–1.54; p = 0.75) | |
| T-Carriers | 254 | 303 | 0.96 (IC = 0.76–1.22; p = 0.7533) | 1.05 (IC = 0.74–1.48; p = 0.78) | |
| miR-146a (rs2910164) | GGb | 184 (0.38) | 330 (0.54) | - | - |
| GC | 246 (0.5) | 242 (0.40) | 1.82 (IC = 1.42–2.35; p = 3.28×10−06) | 1.44(IC = 1.02–2.05; p = 0.04) | |
| CC | 58 (0.12) | 35 (0.06) | 2.97 (IC = 1.88–4.69; p = 2.93×10−06) | 2.18 (IC = 1.21–3.93; p = 0.0091) | |
| Total | 488 | 607 | |||
| G-Alleleb | 614 (0.63) | 902 (0.74) | - | - | |
| C-Allele | 362 (0.37) | 313 (0.26) | 1.7 (IC = 1.32–2.21; p = 0.0001) | 1.47 (IC = 1.03–2.11; p = 0.03) | |
| C-Carriers | 304 | 277 | 1.97 (IC = 1.54–2.51; p = 4.68×10−08) | 1.56 (IC = 1.12–2.18; p = 0.008) |
Population counts are shown as N (frequency).
*Adjusted for sex, ethnicity and age.
b
Genotype or allele used as baseline.
Global p-value to miRSNP-146a p = 0.002. Trend test: miRSNP-146a C-allele, χ2 = 96.6; p = 2.2−16/case-control comparison. HWE of control population: miRSNP-196a-2; χ2 = 0.2; p = 0.65 and miRSNP-146a; χ2 = 0.95; p = 0.34.