Table 1. Case-control criteria.

Clinicala	Pathologic			Phenotype Decision
	NIA/Reagan b	NP score c	NFT Braak stage d
Dementia Group	intermediate or high likelihood	—	—	Neuropathologic AD
	—	moderate or frequent	III–VI
Not Demented Group	low likelihood	—	—	Neuropathologic Control
	—	none or sparse	0, I, or II
	—	none	III or IV

Neuropathologically-confirmed AD and control criteria. Abbreviations: NP: neuritic plaque; NFT: neurofibrillary tangles. AD: Alzheimer's disease.

^aDementia Group met DSM-IV criteria or had a clinical dementia rating greater than zero. Not Demented Group did not meet DSM-IV criteria for dementia, had no mild cognitive impairment and—when available—a clinical dementia rating of zero.

^bHyman and Trojanowski, 1997 [23].

^cMirra et al., 1993 [21].

^dBraak and Braak, 1991 [22].