Figure 9. E3330 attenuates the cisplatin-induced decrease in capsaicin-induced vasodilatation in the rat hindpaw.

Each column represents the mean ± SEM of the capsaicin-evoked changes in blood flow over 15 minutes (capsaicin-stimulated blood flow minus basal blood flow) normalized to the vehicle treated controls. Animals are injected with vehicle (lightly shade columns) or 3 mg/kg cisplatin (dark shaded columns) once a week for three weeks. The animals also were administered vehicle or E3330 (25 mg/kg) orally for five days each week for three weeks. Blood flow was measured at week three of dosing and each week for three weeks after cisplatin and E3330 treatments were discontinued. An asterisk indicates statistical significance between the animals treated with cisplatin and those treated with vehicle, whereas a cross indicates a significant difference in animals treated with cisplatin and E3330 versus those treated with just cisplatin.