Table 3. Clinical characteristics of patients with CTEPH before and after PEA, iPAH before and LuTX, AVS before and after AVR.
| CTEPH (n = 20) | Before PEA | After PEA | p value |
| sRAGE [pg/ml] | 743.29 (582.90) ±117.62 (26.98), [125.33–2085.55] | 688.70 (609.14) ±396.60 (88.68), [141.84–1712.88] | 0.724 |
| Age in years | 60.24 (63.99) ±12.99 (2.91), [31–78] | ||
| F:M ratio n (%) | 5∶15 | ||
| PAPmean [mmHg] | 53.53 (53.00) ±15.26 (3.50), [28.00–90.00] | 27.42 (27.00) ±6.05 (1.39), [18.00–39.00] | <0.001 |
| PVR [dynes·s−1·cm−5] | 701.27 (690.00) ±277.95 (67.41), [329.00–1257.00] | 265.37 (248.00) ±117.62 (26.98), [88.00–539.00] | <0.001 |
| CI [l/min/m2] | 1.92 (2.12) ±1.13 (0.25), [0.00–4.20] | 2.08 (2.20) ±1.42 (0.33), [0.00–3.86] | 0.542 |
| iPAH (n = 7) | Before LuTX | After LuTX | |
| sRAGE [pg/ml] | 1216.05 (1315.27) ±564.95 (213.53), [326.47–1835.31] | 772.83 (519.91) ±694.85 (262.63), [125.95–1880.66] | 0.168 |
| Age in years | 33.43 (34.00) ±6.23 (2.35), [21]–[40] | ||
| F:M ratio n (%) | 5∶2 | ||
| PAP mean [mmHg] | 82.57 (77.00) ±17.63 (6.66), [54.00–103.00] | 22.57 (22.00) ±3.41 (1.29), [19.00–29.00] | <0.001 |
| PVR [dynes·s−1·cm−5] | 1733.60 (1800.00) ±200.71 (89.76), [1452.00–1984.00] | ||
| CI [l/min/m2] | 1.99 (2.00) ±0.27 (0.11), [1.70–2.30] | 4.27 (4.50) ±0.59 (0.34), [3.60–4.70] | 0.074 |
| AVS (n = 15) | Before AVR | After AVR | |
| sRAGE [pg/ml] | 260.26 (216.04) ±171.40 (44.26), [104.01–808.26] | 274.45 (221.26) ±199.24 (51.44), [83.91–874.58] | 0.804 |
| Age in years | 65.23 (64.50) ±10.31 (2.66), [44–86] | ||
| F:M ratio n (%) | 6∶9 | ||
| PAPmean [mmHg] | 18.87 (19.00) ±4.94 (1.28), [9.00–28.00) | ||
| Mean grad | 47.47 (43.00) ±16.22 (4.19), [29.00–84.00] | ||
| Vmax m/s | 4.47 (4.30) ±0.73 (0.19), [3.80–6.20] | ||
| AVA | 0.76 (0.80) ±0.21 (0.06), [0.30–1.00] | ||
| Controls (n = 28) | |||
| sRAGE [pg/ml] | 567.80 (446.78) ±329.09 (62.19) [122.48–1355.13] | ||
| Age in years | 58.50 (62.00) ±20.72 (3.92) [30–91] | ||
| F:M ratio n (%) | 12∶16 |
Reported is mean (median) ± standard deviation (standard error mean), [range].
CTEPH chronic thromboembolic pulmonary hypertensioņ PEA pulmonary endarterectomy, iPAH idiopathic pulmonary arterial hypertension, LuTX double lung transplantation, AVS aortic valve stenosis; AVR aortic valve replacement, Mean grad mean transvalvular pressure gradient, Vmax maximum aortic stenosis jet velocity, AVA aortic valve area, F:M ratio female to male ratio, PAPmean mean pulmonary artery pressure, PVR pulmonary vascular resistance; CI cardiac index, sRAGE soluble receptor for advanced glycation endproducts, n number of patients.