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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: J Med Chem. 2014 Jul 29;57(15):6531–6552. doi: 10.1021/jm500561a

Table 2.

Growth Inhibition of HeLa, HT-29, A549, and HCT116 Cell Lines by Compounds 4, 22, 35–37, 47, and 49 and Reference Compounds 1, 2, VBL, and PTXa

compd IC50 ± SD (nM)
HeLA HT-29 A549 HCT116
4 100 ± 18 90 ± 10 200 ± 50 77 ± 4
22 30 ± 1 60 ± 1 10 ± 4 ndb
35 900 ± 70 1000 ± 1400 1000 ± 300 nd
36 1000 ± 110 800 ± 20 3000 ± 500 nd
37 150 ± 1 200 ± 20 80 ± 7 nd
47 200 ± 10 >10000 >10000 nd
49 800 ± 033 800 ± 1 1000 ± 20 nd
1c 28 ± 9 18 ± 4 20 ± 8 20 ± 2
2c 20 ± 5 130 ± 12 >10000 5 ± 0.4
VBLc 10 ± 0.6 30 ± 0.8 20 ± 2 3 ± 2
PTXc 5 ± 1 8 ± 1.5 7 ± 2 4 ± 0.4
a

Growth inhibition of the indicated cell lines (MTT method); incubation time was 48 h.

b

no data.

c

Lit.10b