Table 3.

Inhibition of Growth of the OVCAR-8 and NCI/ ADR-RES and Messa and Messa/Dx Cell Line Pairs by Compounds 4, 22, 27, and 35–37 and Reference Compounds 1, 2, VRB, VBL, and PTX^a

compd	IC50 ± SD (nM)
	OVCAR-8	NCI/ADR-RES	Messab	Messa/Dx5b
4	45 ± 20	20 ± 0	56 ± 3	76 ± 7
22	7.0 ± 1	1.0 ± 0	1.8 ± 0.2	4.6 ± 0.3
27c	ndd	nd	14 ± 4	16 ± 0.02
35	450 ± 70	200 ± 0	515 ± 29	653 ± 143
36	250 ± 70	90 ± 10	262 ± 74	471 ± 58
37	60 ± 20	17 ± 6	63 ± 7	87 ± 21
1	30 ± 1	420 ± 100	11 ± 6	329 ± 166
2	1.3 ± 0.6	1.3 ± 0.6	2.7 ± 2	2.6 ± 1
VRB	300 ± 0	5000 ± 1000	ndd	nd
VBL	15 ± 7	200 ± 0	3 ± 2	144 ± 61
PTX	5.0 ± 2	3300 ± 1000	4 ± 1	1764 ± 477

^aInhibition of growth of the indicated cell lines.

^bGrowth inhibition data of compounds 11, 12, 14, 18, 19, 27, 29, 38, and 51 are shown in Table 2S, Supporting Information.

^cHydrochloride.

^dNo data.