Table 4.

Growth Inhibition of PC-3, RD, and HepG2 Cell Lines by Compounds 22 and 27 and Reference Compounds VBL, VCR, and PTX^a

compd	IC50 ± SD (nM)
	PC-3	RD	HepG2
22	9.8 ± 5.5	95.3 ± 1.7	274.5 ± 4.8
27	3.9 ± 1.9	803.2 ± 1.9	49.5 ± 1.8
VBL	ndb	52.5 ± 2.5	80.7 ± 2.4
VCR	ndb	nd	177 ± 1.6
PTX	3990 ± 1.9	14200 ± 1.6	2037 ± 2

^aGrowth inhibition of the indicated cell lines (MTT method); incubation time was 48 h.

^bNo data.