Table 5.

Mitotic Index Values of ARAPs 22, 24, 25, 27–30, and 34

compd	IC50 ± SD (nM)	mitotic index ± SD
	K562	(concentrationa)
22	20 ± 6	60 ± 9 (at 10× IC50)
24	30 ± 0	61 ± 1 (at 10× IC50)
25	500 ± 100	69 ± 4 (at 4.0 nMb)
30	950 ± 100	39 ± 6 (at 4.0 nMc)
27	25 ± 7	71 ± 8 (at 10× IC50)
28	19 ± 8	61 ± 1 (at 10× IC50)
29	90 ± 10	47 ± 1 (at 10× IC50)
34	30 ± 0	61 ± 1 (at 10× IC50)
2	nd	65 ± 5 (at 0.1 nM)
controld		3 ± 1

^aHighest concentration possible in mitotic index study was 4.0 μM.

^bIC₅₀ 500 ± 100 nM.

^cIC₅₀ 950 ± 100 nM.

^dUntreated cells.