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Synthetic schemes for bifunctional linker Mal-AO, ZHER2:477-ONH2, (ZHER2:477)2-ONH2, 18F-FBO-ZHER2:477, and 18F-FBO-(ZHER2:477)2. Boc = tert-butoxycarbonyl; DMSO = dimethyl sulfoxide; EDC = 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide; HOBT = N-hy-droxybenzotriazole; MeOH = methanol; NH4OAc = ammonium acetate; PBS = phosphate-buffered saline.
