Table I.
Biodistribution of 131I-labeled T84.66 Cys-diabody in athymic mice bearing LS174T xenografts
| Organ (%ID/g) | 0 h | 2 h | 4 h | 6 h | 18 h | 24 h |
|---|---|---|---|---|---|---|
| Tumor | 2.49 (0.33) | 9.32 (1.73) | 10.02 (0.69) | 9.15 (0.77) | 6.43 (1.05) | 4.79 (1.28) |
| Blood | 36.34 (2.70) | 5.87 (0.63) | 4.04 (0.53) | 3.28 (0.27) | 0.55 (0.13) | 0.36 (0.09) |
| Liver | 8.40 (0.61) | 3.16 (0.81) | 2.66 (0.64) | 1.67 (0.27) | 0.64 (0.24) | 0.32 (0.06) |
| Spleen | 5.67 (0.80) | 2.54 (0.39) | 1.57 (0.20) | 1.30 (0.14) | 0.34 (0.11) | 0.19 (0.04) |
| Kidney | 18.58 (1.22) | 4.03 (0.57) | 2.99 (0.51) | 2.09 (0.25) | 0.47 (0.09) | 0.37 (0.04) |
| Lung | 9.90 (0.69) | 3.40 (0.48) | 2.50 (0.39) | 1.94 (0.17) | 0.46 (0.10) | 0.27 (0.07) |
| Ratios | ||||||
| Tumor:blood | 0.07 | 1.59 | 2.48 | 2.79 | 11.69 | 13.31 |
| Tumor:kidney | 0.13 | 2.31 | 3.35 | 4.38 | 13.68 | 12.95 |
| Tumor:liver | 0.30 | 2.95 | 3.77 | 5.48 | 10.05 | 14.97 |
| Tumor | ||||||
| Tumor weight | 0.58 (0.28) | 0.70 (0.20) | 0.69 (0.09) | 0.63 (0.19) | 1.02 (0.54) | 1.06 (0.53) |
Groups of five mice were analyzed at each time point. Tumor and normal organ uptake are expressed as percentage injected dose per gram (% ID/g). Table values are the means with corresponding standard errors of the means (SEM) shown in parentheses. The ratios presented are the averages of the tumor:blood, tumor:kidney and tumor:liver ratios for the individual mice.