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. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: Circulation. 2004 Mar 8;109(11):1415–1420. doi: 10.1161/01.CIR.0000121727.59564.5B

Figure 3.

Figure 3

[18F]-FESP and [18F]-FHBG accumulations in rat myocardium. An athymic rat was injected intramyocardially with 2×109 pfu of Ad-CMV-D2R80a-IRES-HSV1-sr39tk and scanned (A) on day 2 for D2R80a-dependent accumulation of [18F]-FESP and (B) on day 3 for HSV1-sr39tk– dependent sequestration of [18F]-FHBG. Transaxial [18F]-FESP and [18F]-FHBG images (color) are individually superimposed on an [13N]ammonia perfusion scan (gray scale) for easier localization of tracer accumulation relative to myocardium. Distinct tracer accumulation (arrow) is seen in anterolateral wall of myocardium, corresponding to site of viral injection. Coronal (C) [18F]-FESP and (D) [18F]-FHBG images of thorax, individually overlaid with an [13N]-ammonia perfusion scan, show that lung activity is notably higher in [18F]-FESP than in [18F]-FHBG image, probably because of a slower clearance of [18F]-FESP from lung parenchyma.