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. Author manuscript; available in PMC: 2014 Sep 4.

Published in final edited form as: J Vet Cardiol. 2011 Oct 24;13(4):231–242. doi: 10.1016/j.jvc.2011.06.001

Table 1.

Mean ± SD hourly heart rate (min⁻¹) in 8 cats after oral administration of placebo and one dose of ivabradine (0.1 mg/kg, 0.3 mg/kg, and 0.5 mg/kg).

Time (h)	Placebo	Ivabradine (mg/kg)
Time (h)	Placebo	0.1	0.3	0.5
Baseline	147 ± 21	153 ± 8	154 ± 20	158 ± 12
1	156 ± 27	152 ± 24	149 ± 19^a,^b	144 ± 23^a,^b
2	146 ± 19	133 ± 16^a	119 ± 18^a,^b	109 ± 15^a,^b
3	144 ± 20	133 ± 22	112 ± 20^a,^b	104 ± 11^a,^b,^c
4	157 ± 24	141 ± 19^a	120 ± 13^a,^b	116 ± 14^a,^b,^c
5	167 ± 29	139 ± 18	128 ± 20	118 ± 14
6	156 ± 30	133 ± 20	128 ± 14	117 ± 11
7	157 ± 29	139 ± 18	131 ± 19	119 ± 15
8	157 ± 26	144 ± 16^a	127 ± 23^a,^b	126 ± 19^a,^b
9	148 ± 20	150 ± 28	135 ± 11	130 ± 26
10	146 ± 16	144 ± 22	124 ± 11	129 ± 22
11	146 ± 25	138 ± 15	125 ± 15	128 ± 19
12	141 ± 21	135 ± 16	128 ± 18^a	124 ± 16^a,^b
13	143 ± 18	137 ± 17	126 ± 20	133 ± 17
14	145 ± 17	132 ± 14	132 ± 26	137 ± 21
15	143 ± 17	132 ± 16	133 ± 20	132 ± 20
16	149 ± 25	140 ± 22	135 ± 16	138 ± 20
17	149 ± 25	135 ± 12	136 ± 17	140 ± 21
18	142 ± 21	133 ± 15	138 ± 18	141 ± 27
19	139 ± 16	132 ± 14	144 ± 25	143 ± 25
20	141 ± 16	140 ± 25	134 ± 23	149 ± 25
21	141 ± 22	133 ± 11	131 ± 18	132 ± 15
22	142 ± 19	134 ± 11	141 ± 28	126 ± 17

^a

Significant differences (P < 0.05) compared to placebo.

^b

Significant differences (P < 0.05) compared to ivabradine (0.1 mg/kg).

^c

Significant differences (P < 0.05) compared to ivabradine (0.3 mg/kg). Data were compared only at hours 0, 1, 2, 3, 4, 8, and 12.