Table 2. Cross-validated sensitivity at the specificity closest to 90% and the AUC and pAUC of the two models (all in %).
Sensitivity* | Specificity** | AUC | Partial AUC*** | |
Development set | ||||
Model 1: AGE + FOBT | 75.31 | 90.2 | 89.52 | 6.65 |
Model 2: AGE + FOBT + CALB | 83.95 | 90.2 | 92.05 | 7.02 |
Development set (Leave-one-out cross-validation) | ||||
Model 1: AGE + FOBT | 75.31 | 90.2 | 87.78 | 5.62 |
Model 2: AGE + FOBT + CALB | 82.72 | 90.2 | 89.81 | 5.70 |
Validation set | ||||
Model 1: AGE + FOBT | 79.79 | 90 | 90.65 | 7.34 |
Model 2: AGE + FOBT + CALB | 79.79 | 90 | 92.74 | 7.71 |
AUC. Area under the curve; pAUC, partial area under the curve, FOBT. Fecal occult blood test; CALB, calgranulin B.
*Sensitivity when the specificity of the model developing samples is set at closest to 90%.
**Observed specificity closest to 90%.
***Partial AUC for specificities range from 90% to 100%.