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. 2014 Sep 4;10(9):e1004325. doi: 10.1371/journal.ppat.1004325

Figure 7. Role of the phagocyte NADPH oxidase in granuloma formation and BCG sequestration.

Figure 7

Three days and 4 weeks after BCG infection, wild-type, Ncf1mutant and rescue mice were sacrificed and lungs were fixed and sectioned. Representative hematoxylin and eosin (H&E) stained lung histology focused on (A) focal clusters at 3 days and (D) granuloma formation at 4 weeks. Representative acid phosphatase activity in lung lesions showing activated macrophages at 3 days (B) and 4 weeks (E). Ziehl-Neelsen staining of lung lesions showing distribution of acid fast bacilli at 3 days (C) and 4 weeks (F). Magnifications were ×200.