Table 5.
Comparison of IOP- and MD-related parameters between patients with and without progression of visual field loss
| Parameter | Progression of visual field loss
|
P-value | |
|---|---|---|---|
| − | + | ||
| Subjects, N | 9 | 5 | – |
| Age (years) | 67.7±7.3 | 63.4±7.1 | 0.3578* |
| Male/female | 6/3 | 3/2 | 0.6224† |
| Right/left | 5/4 | 2/3 | 0.5000† |
| Refraction, diopters | −3.4±2.6 | −3.8±3.2 | 0.8483* |
| IOP, mmHg | |||
| Mean before baseline | 13.7±2.4 | 13.0±1.8 | 0.6035* |
| Baseline | 14.6±3.2 | 13.2±1.2 | 0.3053* |
| 3 months | 12.9±2.8 | 12.0±0.9 | 0.4265* |
| 12 months | 12.2±2.6 | 14.0±1.7 | 0.1776* |
| 24 months | 11.9±2.0 | 11.2±1.3 | 0.4947* |
| 36 months | 12.3±3.6 | 12.4±1.5 | 0.9649* |
| IOP reduction, % | |||
| 3 months | 10.0±14.7 | 8.9±5.1 | 0.8417* |
| 12 months | 13.9±17.8 | −5.8±5.7 | 0.0160* |
| 24 months | 16.8±12.2 | 14.6±11.8 | 0.7637* |
| 36 months | 14.5±15.7 | 5.6±11.6 | 0.2925* |
| Mean for 36 months | 13.2±12.5 | 8.9±6.9 | 0.4554* |
| MD values, dB | |||
| Mean for 1 year before switching | −5.5±4.9 | −6.8±4.2 | 0.6401* |
| Baseline | −5.7±5.3 | −6.2±4.2 | 0.8552* |
| 12 months | −4.8±4.8 | −6.9±4.4 | 0.4673* |
| 24 months | −4.9±4.9 | −7.6±4.7 | 0.3902* |
| 36 months | −4.8±5.0 | −7.0±5.0 | 0.5092* |
| MD slope (dB/per year) | |||
| From 12 months before switching to baseline | −0.3±0.7 | 0.0±0.8 | 0.4405* |
| From baseline to 12 months | 0.8±1.2 | −0.7±0.9 | 0.0274* |
| From 12 to 24 months | −0.1±0.9 | −0.6±1.3 | 0.4705* |
| From 24 to 36 months | 0.1±0.7 | 0.6±1.0 | 0.3873* |
| Mean from baseline to 36 months | 0.2±0.3 | −0.5±0.7 | 0.1075* |
Notes:
*
Two-tailed unpaired t-test
†
Fisher’s exact test.
Abbreviations: IOP, intraocular pressure; MD, mean deviation.