Table 1. Estimated probability of virologic suppression and absolute CD4+ cell count change from baseline.
Estimated Probability of Virologic Suppression at week 48 Mean (95% CrI) | Estimated CD4+ cell count change from baseline to week 48 Mean (95% CrI) | |||||||
Third agent | TDF/FTC | ABC/3TC | Other | Backboneunadjusted | TDF/FTC | ABC/3TC | Other | Backboneunadjusted |
N = 26 studies | N = 26 studies | N = 26 studies | N = 22 studies | N = 28 studies | N = 28 studies | N = 28 studies | N = 24 studies | |
ATV/r | 0.74 (0.68,0.79) | 0.72 (0.66,0.78) | 0.68 (0.62,0.74) | 0.71 (0.66,0.76) | 188.5 (176.5,200.6) | 204.7 (191.4,218.4) | 151.5 (134.2,169.0) | 181.4 (171.0,191.8) |
DRV/r | 0.76 (0.68,0.83) | 0.74 (0.66,0.81) | 0.71 (0.62,0.78) | 0.73 (0.65,0.80) | 197.5 (175.4,219.4) | 213.8 (191.8,235.3) | 160.5 (135.8,185.1) | 194.5 (173.6,215.4) |
DTG | 0.86 (0.81,0.90) | 0.85 (0.80,0.88) | 0.82 (0.77,0.87) | 0.84 (0.79,0.87) | 224.7 (205.6,243.7) | 240.9 (224.3,257.7) | 187.7 (166.5,209.1) | 226.8 (210.7,242.6) |
EFV | 0.77 (0.74,0.79) | 0.75 (0.72,0.78) | –0.72 (0.68,0.75) | 0.75 (0.74,0.76) | 186.8 (179.5,194.0) | 203.0 (193.2,212.9) | 149.7 (135.0,164.5) | 179.1 (175.1,183.1) |
EVG/c | 0.80 (0.74,0.85) | 0.79 (0.72,0.84) | 0.76 (0.69,0.82) | 0.78 (0.72,0.83) | 203.3 (184.8,221.7) | 219.5 (200.1,238.7) | 166.3 (144.2,189.0) | 196.1 (178.3,213.4) |
LPV/r | 0.70 (0.65,0.76) | 0.68 (0.62,0.74) | 0.65 (0.58,0.71) | 0.68 (0.62,0.73) | 198.0 (181.7,214.5) | 214.2 (197.5,231.1) | 161.0 (140.5,181.6) | 192.1 (176.8,207.5) |
RAL | 0.83 (0.77,0.87) | 0.81 (0.75,0.86) | 0.78 (0.72,0.84) | 0.80 (0.75,0.85) | 221.3 (200.5,242.2) | 237.5 (217.7,257.5) | 184.2 (160.8,207.8) | 219.6 (200.4,239.1) |
RPV | 0.80 (0.76,0.84) | 0.79 (0.74,0.83) | 0.76 (0.71,0.80) | 0.78 (0.75,0.82) | 201.4 (187.3,215.2) | 217.6 (202.0,232.8) | 164.3 (145.8,183.3) | 193.8 (181.1,206.5) |
Note: Estimates derived from this meta-analysis may differ from that of any given RCT, due to statistical aggregation of data from several trials.