Table 3. Difference (95% CrI) between direct clinical trial data and indirect model estimates.
Third-agentComparisons | VirologicSuppression | CD4+ | TC | HDL | LDL | TG |
ATV/r v. ATV | 0.85 (0.42,1.75) | 17.26 (−31.72,65.88) | 4.06 (−7.16,15.21) | - | - | −2.09 (−33.89,30.41) |
ATV/r v. DRV/r | - | 2.73 (−76.85,81.91) | 2.87 (−83.98,90.72) | 3.07 (−2.63,8.79) | −4.36 (−77.61,69.34) | −21.6 (−49.40,5.78) |
ATV/r v. FPV/r | 0.80 (0.29,2.20) | −5.39 (−72.22,62.95) | - | - | - | - |
ATV/r v. LPV/r | 1.08 (0.73,1.63) | 6.45 (−18.75,31.74) | 3.86 (−1.80,9.57) | 0.50 (−1.32,2.30) | 0.46 (−4.07,5.00) | 8.18 (−8.63,25.25) |
ATV/r v. SQV/r | 1.43 (0.52,3.97) | −6.97 (−333.40,319.80) | −2.30 (−201.20,199.00) | - | - | 9.63 (−190.30,209.00) |
DRV/r v. LPV/r | 1.03 (0.61,1.72) | 3.70 (−26.68,34.16) | - | - | - | - |
DTG v. DRV/r | 1.05 (0.54,2.05) | 0.41 (−496.50,497.90) | −0.94 (−82.29,79.6) | −0.53(−27.93,26.40) | 0.37 (−63.54,63.98) | −12.62 (−191.50,167.00) |
DTG v. RAL | 1.04 (0.62,1.75) | 3.58 (−24.46,31.33) | 0.47 (−77.39,78.40) | 0.16 (−29.47,29.95) | −1.02 (−62.93,60.38) | 12.76 (−16.68,42.08) |
EVG/c v. ATV/r | 1.12 (0.63,1.99) | 21.37 (−437.7,469.5) | - | - | - | - |
FPV/r v. LPV/r | 0.91 (0.63,1.32) | −2.38 (−29.92,25.28) | − | - | - | - |
LPV/r v. NFV | - | −2.60 (−32.52,27.99) | - | - | - | - |
Consistency evaluation for virologic suppression are derived OR of direct estimate divided by indirect estimates; CD4+, TC, HDL, LDL, and TG are the mean differences of direct and indirect estimates.