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. 2014 Sep 4;9(9):e105653. doi: 10.1371/journal.pone.0105653

Table 3. Difference (95% CrI) between direct clinical trial data and indirect model estimates.

Third-agentComparisons VirologicSuppression CD4+ TC HDL LDL TG
ATV/r v. ATV 0.85 (0.42,1.75) 17.26 (−31.72,65.88) 4.06 (−7.16,15.21) - - −2.09 (−33.89,30.41)
ATV/r v. DRV/r - 2.73 (−76.85,81.91) 2.87 (−83.98,90.72) 3.07 (−2.63,8.79) −4.36 (−77.61,69.34) −21.6 (−49.40,5.78)
ATV/r v. FPV/r 0.80 (0.29,2.20) −5.39 (−72.22,62.95) - - - -
ATV/r v. LPV/r 1.08 (0.73,1.63) 6.45 (−18.75,31.74) 3.86 (−1.80,9.57) 0.50 (−1.32,2.30) 0.46 (−4.07,5.00) 8.18 (−8.63,25.25)
ATV/r v. SQV/r 1.43 (0.52,3.97) −6.97 (−333.40,319.80) −2.30 (−201.20,199.00) - - 9.63 (−190.30,209.00)
DRV/r v. LPV/r 1.03 (0.61,1.72) 3.70 (−26.68,34.16) - - - -
DTG v. DRV/r 1.05 (0.54,2.05) 0.41 (−496.50,497.90) −0.94 (−82.29,79.6) −0.53(−27.93,26.40) 0.37 (−63.54,63.98) −12.62 (−191.50,167.00)
DTG v. RAL 1.04 (0.62,1.75) 3.58 (−24.46,31.33) 0.47 (−77.39,78.40) 0.16 (−29.47,29.95) −1.02 (−62.93,60.38) 12.76 (−16.68,42.08)
EVG/c v. ATV/r 1.12 (0.63,1.99) 21.37 (−437.7,469.5) - - - -
FPV/r v. LPV/r 0.91 (0.63,1.32) −2.38 (−29.92,25.28) - - -
LPV/r v. NFV - −2.60 (−32.52,27.99) - - - -

Consistency evaluation for virologic suppression are derived OR of direct estimate divided by indirect estimates; CD4+, TC, HDL, LDL, and TG are the mean differences of direct and indirect estimates.