Table 1. Cancer-related genes whose levels of expression were significantly altered in androgen-independent prostate cancer cell lines treated with the indicated concentrations of L-28.

	Gene name	Accession number	Fold-change
			DU145 (2 µM)	PC-3 (2 µM)	DU145 (5 µM)	PC-3 (5 µM)
DNA synthesis and repair	BCL6	NM_001706.2	2	1	3	2
	MLL	NM_005933.2	1	1	2	2
	MYBL2	NM_002466.2	-1	-5	-3	-20
	TYMS	NM_001071.1	-1	-2	-2	-2
	TOP2A	NM_001067.2	-2	-3	-3	-7
	IRF1	NM_002198.1	-1	2	2	2
	MTA1	NM_004689.2	1	1	2	2
	MYC	NM_002467.3	1	1	2	2
	RRM1	NM_001033.3	-1	-2	-2	-3
Cell proliferation, growth, and differentiation	AREG	NM_001657.2	2	2	6	2
	BIRC5	NM_001012270.1	-2	-3	-3	-9
	IGFBP3	NM_000598.4	-1	2	-3	2
	PPARG	NM_138711.3	2	2	5	2
	SIAH1	NM_001006610.1	2	1	2	2
	EGFR	NM_005228.3	2	2	4	2
	IL6	NM_000600.1	-1	3	2	3
	TNFRSF10B	NM_003842.3	2	2	3	2
	TGFA	NM_001099691.1	2	2	2	2
	FGFR3	NM_022965.2	-1	-2	-2	-3
	MET	NM_000245.2	1	2	2	3
	PIK3CA	NM_006218.2	1	1	2	2
Cell Cycle regulation and progression	BIRC5	NM_001012270.1	-2	-3	-3	-9
	CCNA2	NM_001237.2	-1	-2	-2	-4
	CCND3	NM_001760.2	-2	-2	-5	-5
	CCNE1	NM_001238.1	1	-2	2	-2
	CDC2	NM_001786.2	-1	-4	-2	-9
	CDKN1A	NM_000389.2	2	2	4	2
	CDKN2C	NM_001262.2	-2	-2	-5	-2
	CEBPA	NM_004364.2	2	1	2	2
	MYBL2	NM_002466.2	-1	-5	-3	-20
	SIAH1	NM_001006610.1	2	1	2	2
	GADD45A	NM_001924.2	1	2	2	2
Cell migration and adhesion	CAV1	NM_001753.3	-4	-1	-7	-2
	CTGF	NM_001901.2	-1	-2	-3	-5
	FGF2	NM_002006.4	2	2	7	2
	L1CAM	NM_024003.2	2	2	2	4
	LAMB1	NM_002291.2	1	1	-2	2
	PLAUR	NM_002659.2	2	2	4	2
	SERPINE1	NM_000602.2	4	2	3	2
Immune and Inflammatory response	AREG	NM_001657.2	2	2	6	2
	IL6	NM_000600.1	-1	3	2	3
	MET	NM_000245.2	1	2	2	3