Table 2. Cancer-related genes whose levels of expression were significantly altered in androgen-dependent prostate cancer cell lines treated with the indicated concentrations of L-28.
| Gene Name | Accession number | Fold-change | ||||
|---|---|---|---|---|---|---|
| 22Rv1 (2µM) | LNCaP (2 µM) | 22Rv1 (5 µM) | LNCaP (5 µM) | |||
| DNA synthesis and repair | ETS2 | NM_005239.4 | 1 | 1 | 3 | 3 |
| E2F1 | NM_005225.1 | -1 | -2 | -3 | -5 | |
| MYBL2 | NM_002466.2 | -2 | -2 | -4 | -3 | |
| PCNA | NM_182649.1 | -1 | -2 | -3 | -3 | |
| RAD54L | NM_003579.2 | -1 | -3 | -2 | -4 | |
| TOP1 | NM_003286.2 | 1 | 1 | 2 | 2 | |
| TYMS | NM_001071.1 | -1 | -2 | -3 | -2 | |
| Cell proliferation, growth, and differentiation | BRAF | NM_004333.3 | 1 | 1 | 3 | 2 |
| EPS8 | NM_004447.5 | 1 | 1 | 2 | 2 | |
| ETV1 | NM_004956.3 | 1 | -1 | 3 | -2 | |
| FGFR1 | NM_015850.2 | 1 | 1 | 7 | 2 | |
| IGFBP3 | NM_000598.4 | 2 | 1 | 2 | 3 | |
| GRB7 | NM_005310.2 | 1 | -1 | 3 | -2 | |
| GADD45A | NM_001924.2 | 2 | 1 | 7 | 2 | |
| IFNGR1 | NM_000416.1 | 1 | 1 | 2 | 2 | |
| MCL1 | NM_021960.3 | 1 | 1 | 3 | 2 | |
| NQO1 | NM_000903.2 | 2 | 2 | 10 | 4 | |
| PTPRG | NM_002841.2 | 2 | -1 | 4 | 2 | |
| PIK3CA | NM_006218.2 | 1 | 1 | 2 | 2 | |
| YES1 | NM_005433.3 | 1 | 1 | 2 | 2 | |
| Cell cycle regulation and progression | CCNE1 | NM_001238.1 | -1 | -1 | 2 | -2 |
| CDC2 | NM_001786.2 | -2 | -1 | -2 | -2 | |
| E2F1 | NM_005225.1 | -1 | -2 | -3 | -5 | |
| JUN | NM_002228.3 | -1 | 1 | 2 | 2 | |
| JUN B | NM_002229.2 | 1 | 2 | 2 | 3 | |
| MYB | NM_005375.2 | -1 | -1 | -2 | -2 | |
| MYBL2 | NM_002466.2 | -2 | -2 | -4 | -3 | |
| PML | NM_033240.2 | 1 | 1 | 2 | 2 | |
| PTEN | NM_000314.3 | 2 | 1 | 3 | 2 | |
| RARA | NM_000964.2 | 1 | 2 | 2 | 2 | |
| Cell migration and adhesion | ETV1 | NM_004956.3 | 1 | -1 | 3 | -2 |
| JUN | NM_002228.3 | -1 | 1 | 2 | 2 | |
| TGFBR3 | NM_003243.3 | 1 | -1 | 3 | 2 | |
| Immune and inflammatory responses | PTGS2 (COX2) | NM_000963.1 | -2 | -2 | -2 | -3 |
| REL | NM_002908.2 | 1 | 1 | 3 | 2 | |