Skip to main content
. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: Hum Mutat. 2011 Apr 7;32(6):661–668. doi: 10.1002/humu.21490

Figure 1.

Figure 1

A) Predictions of neutral (n = 16) BRCA1 missense mutations using three algorithms with four alignments each. The four alignments are represented by SIFT (SIFT), Align-GVGD (A-GVGD), PolyPhen-2 (PPH2), and Uniprot 50% (Uniprot 50%). The prediction categories for PolyPhen-2 Possibly Damaging and Probably Damaging have been abbreviated to ‘Possibly D’ and ‘Probably D’. The algorithm Xvar employs its own alignment. B) Predictions of deleterious (n = 17) BRCA1 missense mutations using three algorithms with four alignments each.