. Author manuscript; available in PMC: 2014 Sep 4.

Published in final edited form as: Hum Mutat. 2011 Apr 7;32(6):661–668. doi: 10.1002/humu.21490

Table 3.

Area under the curve (AUC) from receiver operating curves for each algorithm using each alignment using probabilities and scores associated with each mutation prediction

Algorithms	Alignments	AUC	CI
SIFT	SIFT	0.777	(0.690, 0.865)
	Align-GVGD	0.790	(0.702, 0.877)
	PolyPhen-2	0.730	(0.643, 0.818)
	Uniprot 50%	0.487	(0.400, 0.575)

AGVGD	SIFT	0.747	(0.659, 0.835)
	Align-GVGD	0.791	(0.703, 0.878)
	PolyPhen-2	0.500	(0.412, 0.588)
	Uniprot 50%	0.500	(0.412, 0.588)

PPH2	SIFT	0.773	(0.686, 0.861)
	Align-GVGD	0.779	(0.692, 0.867)
	PolyPhen-2	0.792	(0.704, 0.879)
	Uniprot 50%	0.750	(0.662, 0.838)

Xvar	Xvar	0.790	(0.703, 0.878)

95% confidence intervals are also reported.