Table 3.

Individual and combined biomarker performance data for bladder cancer detection

Biomarker	Area under the Curve	95% CI	No. of Correctly Predicted Events	No. of Correctly Predicted Nonevents	No. of Nonevents Predicted as Events	No. of Events Predicted as Nonevents	Sen.	Spec.	PPV	NPV
IL8	0.7902	0.7315 – 0.8488	74	100	33	22	77.1%	75.2%	69.2%	82.0%
MMP9	0.7432	0.6781 – 0.8083	79	81	52	17	82.3%	60.9%	60.3%	82.7%
SERPINA1	0.7870	0.728 – 0.8459	70	96	37	26	72.9%	72.2%	65.4%	78.7%
ANG	0.7768	0.7173 – 0.8364	85	69	64	11	88.5%	51.9%	57.0%	86.2%
VEGFA	0.7947	0.7356 – 0.8539	89	86	51	16	84.8%	62.8%	63.6%	84.3%
CA9	0.8050	0.7488 – 0.8612	66	107	26	30	68.8%	80.5%	71.7%	78.1%
MMP10	0.7868	0.7284 – 08451	78	86	47	18	81.3%	64.7%	62.4%	82.7%
APOE	0.7549	0.6933 – 0.8164	82	72	61	14	85.4%	54.1%	57.3%	83.7%
SERPINE1	0.7818	0.7230 – 0.8407	79	86	47	17	82.3%	64.7%	62.7%	83.5%
SDC1	0.8024	0.7451 – 0.8598	75	99	34	21	78.1%	74.4%	68.8%	82.5%
All 10 biomarkers	0.8475	0.7958 – 0.8992	76	105	28	20	79.2%	78.9%	73.1%	84.0%

CI, confidence interval