Table 4. Effect of genotype at rs11781886 and rs2228013 on total prostate cancer risk in each intervention arm of the SELECT case-control cohort.

Genotype	Intervention arm
	Placebo N = 1220			Vitamin E N = 1318			Selenium N = 1247			Vitamin E + Selenium N = 1216
rs11781886	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
TT	1.000	Ref	Ref	1.142	0.891-1.463	0.2951	1.074	0.836-1.379	0.5753	1.218	0.947-1.567	0.1238
CT	1.175	0.895-1.542	0.2448	1.500	1.124-1.971	0.0036	1.218	0.918-1.617	0.1710	0.966	0.733-1.272	0.8048
CC	1.144	0.690-1.898	0.6015	1.233	0.744-2.042	0.4162	1.676	1.011-2.777	0.0450	0.987	0.541-1.803	0.9671
p trend	0.2897			0.8548			0.6457			0.0634
rs2228013
GG	1.000	Ref	Ref	1.165	0.968-1.403	0.1066	1.064	0.882-1.283	0.5191	1.037	0.859-1.252	0.7074
AG or AA	0.912	0.574-1.447	0.6952	1.137	0.742-1.740	0.5557	1.365	0.876-2.128	0.1685	0.740	0.456-1.203	0.2247
p trend	0.6952			0.8330			0.2934			0.4722