Table 5. Effect of genotype at rs11781866 and rs2228013 on low grade prostate cancer risk in each arm of the SELECT case-control cohort.

Genotype	Intervention arm
	Placebo			Vitamin E			Selenium			Vitamin E + Selenium
Low grade cases
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
All genotypes	1.00	ref	Ref	1.070	0.867-1.319	0.5294	1.004	0.812-1.241	0.9728	0.932	0.752-1.154	0.5166
rs11781886
TT	1.000	ref	Ref	1.159	0.864-1.554	0.3251	1.018	0.754-1.375	0.9054	1.182	0.874-1.599	0.2764
CT	1.261	0.917-1.734	0.1537	1.267	0.910-1.765	0.1608	1.172	0.836-1.643	0.3560	0.915	0.658-1.273	0.5977
CC	1.160	0.649-2.074	0.6156	1.341	0.742-2.424	0.3312	1.811	1.016-3.228	0.0441	1.010	0.487-2.095	0.9795
p trend	0.2212			0.7016			0.6488			0.0802
rs2228013
GG	1.000	ref	Ref	1.079	0.865-1.346	0.4997	0.987	0.789-1.235	0.9082	0.956	0.764-1.197	0.6968
AG or AA	0.974	0.568-1.670	0.9232	1.036	0.621-1.728	0.8915	1.386	0.833-2.308	0.2091	0.761	0.431-1.343	0.3461
p trend	0.9232			0.9705			0.3317			0.6115