Table 6. Effect of genotype at rs11781866 and rs2228013 on high grade prostate cancer risk in each arm of the SELECT case-control cohort.

Genotype	Intervention arm
	Placebo			Vitamin E			Selenium			Vitamin E + Selenium
High grade cases
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
All genotypes	1.00	Ref	Ref	1.250	0.942-1.658	0.1224	1.201	0.902-1.598	0.2099	1.212	0.911-1.612	0.1868
rs11781886
TT	1.000	Ref	Ref	1.015	0.672-1.533	0.9447	1.059	0.710-1.579	0.7796	1.297	0.871-1.931	0.2002
CT	1.027	0.656-1.609	0.9058	1.753	1.146-2.680	0.0096	1.308	0.839-2.039	0.2355	1.078	0.692-1.678	0.7401
CC	1.164	0.519-2.611	0.7123	1.131	0.515-2.484	0.7600	1.325	0.559-3.140	0.5224	1.079	0.435-2.676	0.8695
p trend	0.7586			0.3596			0.6433			0.4247
rs2228013
GG	1.000	Ref	Ref	1.209	0.896-1.630	0.2138	1.173	0.869-1.584	0.2969	1.197	0.887-1.616	0.2407
AG or AA	0.909	0.444-1.862	0.7938	1.223	0.635-2.354	0.5472	1.240	0.593-2.589	0.5677	0.928	0.448-1.922	0.8413
p trend	0.7938			0.8278			0.7724			0.7592