Table 2.
Permissive HLA-DPB1 mismatch (N = 585) |
HLA-DPB1 match (N = 239) |
Non-Permissive HLA-DPB1 mismatch (N = 457) |
Non-Permissive HLA-DPB1 GvH (N=226) |
Non-Permissive HLA-DPB1 HvG (N=231) |
|||||
---|---|---|---|---|---|---|---|---|---|
Ref. | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Overall mortalitya | 1 | 0.94 (0.78–1.14) | 0.56 | 1.16 (0.99–1.35) | 0.05 | 1.11 (0.92–1.35) | 0.27 | 1.20 (1.00–1.44) | 0.05 |
Treatment-related mortalityb | 1 | 0.86 (0.68–1.11) | 0.03 | 1.3 (1.06–1.53) | 0.009 | 1.29 (1.03–1.60) | 0.03 | 1.27 (1.01–1.58) | 0.04 |
Relapsec | 1 | 1.31 (0.99–1.73) | 0.05 | 0.80 (0.62–1.05) | 0.1 | 0.55 (0.37–0.80) | 0.002 | 1.09 (0.8–1.48) | 0.6 |
aGVHD C–Dd | 1 | 0.96 (0.73–1.26) | 0.77 | 1.27 (1.02–1.57) | 0.03 | 1.34 (1.03–1.74) | 0.03 | 1.20 (0.92–1.56) | 0.17 |
adjusted for disease, disease status, GVHD prophylaxis, use of in vivo T cell depletion, preparative regimen, and recipient age at transplant.
adjusted for disease status, GVHD prophylaxis, use of in vivo T cell depletion, preparative regimen and recipient age at transplant.
adjusted for disease and disease status.
adjusted for disease, disease status, graft type and year of transplant.