Table 4.
Permissive HLA-DPB1 mismatch + DPA1 match (N = 321) |
Permissive HLA-DPB1 mismatch + DPA1 mismatch (N = 264) |
HLA-DPB1 match + HLA- DPA1 match (N = 229) |
HLA-DPB1 match + HLA- DPA1 mismatch (N=10) |
Non-Permissive HLA-DPB1 mismatch + HLA-DPA1 match (N = 219) |
Non-Permissive HLA-DPB1 mismatch + HLA-DPA1 mismatch (N = 238) |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Ref. | HR (95% CI) | p- value |
HR (95% CI) | p- value |
HR (95% CI) | p- value |
HR (95% CI) | p- value |
HR (95% CI) | p- value |
|
Overall mortalitya | 1 | 0.92 (0.75–1.13) | 0.42 | 0.87 (0.71–1.08) | 0.22 | 2.31 (1.22–4.41) | 0.011 | 1.22 (0.99–1.50) | 0.06 | 1.03 (0.84–1.27) | 0.76 |
Treatment-related mortalityb | 1 | 1.01 (0.78–1.31) | 0.93 | 0.84 (0.63–1.10) | 0.2 | 1.97 (0.86–4.50) | 0.11 | 1.39 (1.08–1.78) | 0.01 | 1.19 (0.93–1.53) | 0.16 |
Relapsec | 1 | 0.74 (0.54–1.04) | 0.08 | 1.13 (0.83–1.54) | 0.44 | 2.70 (0.981–7.39) | 0.05 | 0.84 (0.59–1.19) | 0.33 | 0.62 (0.43–0.89) | 0.01 |
aGVHD C–Dd | 1 | 1.11 (0.83–1.49) | 0.49 | 1.00 (0.74–1.37) | 0.98 | 1.02 (0.32–3.21) | 0.98 | 1.22 (0.90–1.66) | 0.19 | 1.42 (1.06–1.89) | 0.02 |
adjusted for disease, disease status, GVHD prophylaxis, use of in vivo T cell depletion, preparative regimen, and recipient age at transplant.
adjusted for disease status, GVHD prophylaxis, use of in vivo T cell depletion, preparative regimen and recipient age at transplant.
adjusted for disease and disease status.
adjusted for disease, disease status, graft type and year of transplant.