Table 1.
Number of DNA methylation sites and regions showing significant changes in methylation in xenografts treated with SGI-110 or vehicle.
| Control vs. | Decreased Methylation | Increased Methylation | ||
|---|---|---|---|---|
| SGI-110 | Total | Δ Beta ≥.2b | Total | Δ Beta ≥.2b |
| CpG Sites | 62,964 | 9,971 | 781 | 165 |
| CpG Regionsc | 10,570 | 54 | 15 | 0 |
Methylation of CpG sites was determined using Infinium HumanMethylation450 arrays and was expressed as beta values ranging from 0 (unmethylated) to 1 (totally methylated). Significant changes: P<.01 (ANOVA) and FDR<.05.
b
ΔBeta = Difference in beta values between Control and SGI-110 groups.
c
CpG islands plus shores and shelves.