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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Clin Cancer Res. 2014 Jun 24;20(17):4636–4646. doi: 10.1158/1078-0432.CCR-14-0305

Figure 5.

Figure 5

Ectopic expression of miR-409 in the prostate gland transforms normal prostate epithelia, promotes tumorigenecity, EMT and stemness in vivo. A, Comparison of normal prostate and miR-409 expressing prostates. Top row represents green fluorescence for cells containing control GFP plasmid or miR-409 GFP expressing plasmid. Bottom panel represent tumor specific NIR dye (IR783) uptake in control or miR-409 expressing prostates. B, H&E staining of normal control prostate and adenocarcinoma lesions of miR-409 overexpressing prostates (40x), followed by miRNA detection of scramble miRNA and miR-409-5p/-3p of control and miR-409 expressing tissues by ISH and QD detection (40x). C, IHC staining of Ki-67, STAG2, RSU1, vimentin and p-AKT in control prostate and miR-409 expressing prostate tissues (20x).