Table 2.
Univariate and multivariate logistic regression analysis of factors associated with pathologic response
| Univariate analysis | Multivariate analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | Case | PathCR | <pathCR | OR | 95% CI | p value | OR | 95% CI | p value |
| Ages | |||||||||
| ≤55 | 12 | 2 | 10 | 0.278 | 0.054-1.424 | 0.125 | 0.302 | 0.049-1.874 | 0.199 |
| >55 | 43 | 18 | 25 | ||||||
| Gender | |||||||||
| Male | 34 | 9 | 25 | 0.372 | 0.104-1.030 | 0.056 | 0.415 | 0.103-1.676 | 0.217 |
| Female | 21 | 11 | 10 | ||||||
| Tumor size (cm) | |||||||||
| ≤5 | 35 | 14 | 21 | 1.556 | 0.482-5.019 | 0.460 | 0.617 | 0.131-2.905 | 0.541 |
| >5 | 20 | 6 | 14 | ||||||
| Tumor location | |||||||||
| Cervical/upper thoracic | 14 | 7 | 7 | 2.154 | 0.625-7.421 | 0.224 | 1.757 | 0.372-8.298 | 0.477 |
| Middle/lower thoracic | 41 | 13 | 28 | ||||||
| Histologic grade | |||||||||
| G1 | 8 | 3 | 5 | 0.873 | 0.172-4.429 | 0.870 | nd | nd | nd |
| G2 | 27 | 11 | 16 | 1.400 | 0.250-7.830 | 0.702 | nd | nd | nd |
| G3 | 20 | 6 | 14 | ||||||
| T status | |||||||||
| T1/2 | 14 | 6 | 8 | 1.446 | 0.419-4.997 | 0.560 | nd | nd | nd |
| T3 | 41 | 14 | 27 | ||||||
| N status | |||||||||
| Negative | 20 | 10 | 10 | 2.500 | 0.797-7.839 | 0.116 | 0.508 | 0.027-9.577 | 0.651 |
| Positive | 35 | 10 | 25 | ||||||
| M status | |||||||||
| M0 | 39 | 16 | 23 | 2.087 | 0.586-7.651 | 0.267 | 1.250 | 0.212-7.368 | 0.805 |
| M1-lym | 16 | 4 | 12 | ||||||
| Clinical stage | |||||||||
| IandII | 21 | 10 | 11 | 2.182 | 0.705-6.756 | 0.176 | 2.102 | 0.109-40.483 | 0.623 |
| III | 34 | 10 | 24 | ||||||
| LOC285194 | |||||||||
| low | 27 | 4 | 23 | 0.130 | 0.036-0.478 | 0.002* | 0.133 | 0.028-0.624 | 0.011* |
| high | 28 | 16 | 12 | ||||||
PathCR, pathologic complete response; OR, odd ratio; CI, confidence interval; M1-lym, distant lymph node metastasis; nd, not done. *p < 0.05.