Table 2.
Inclusion and exclusion criteria
| Inclusion criteria | |
| 1 | MVA patients with typical symptom and positive adenosine-stress CMR and with normal coronary artery in CCTA or coronary angiography. |
| 2 | Definition of positive adenosine-stress CMR: perfusion defect >25% of transmurality (by two radiologists based on visual assessment and qualitative assessment in core-lab) |
| 3 | Gender: female |
| 4 | Age: 18 to 80-years-old |
| Exclusion criteria | |
| 1 | Patient has a contraindication to CMR contrast media or CMR imaging |
| 2 | LVEF <50% |
| 3 | Any heart rhythm abnormality other than sinus rhythm |
| 4 | Valvular heart disease with more than moderate degree |
| 5 | Renal failure |
| 6 | Congestive heart failure |
| 7 | Myocardial infraction |
| 8 | Myocarditis |
| 9 | Congenital heart disease |
| 10 | Pericarditis |
| 11 | Variant angina (positive provocation test with ergonovine or acetylcholine) |
| 12 | GERD (conformed by esophagogastroduodenoscopy) |
| 13 | Pregnant women, suspected pregnant women or lactating women |
| 14 | QT prolongation syndrome or taking drugs that prolong the QT interval: |
| - Antiarrhythmics class IA; quinidine, procainamide | |
| - Antiarrhythmics class III; amiodarone, sotalol | |
| 15 | Pre-analytical within 30 days of screening in a clinical trial that may affect the influence of udenafil: |
| - Other PDE-5 inhibitors (for example sildenafil, tadalafil) | |
| - Nitrates/NO donor (for example nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, amyl nitrate/nitrite, sodium nitroprusside, and nicorandil) | |
| 16 | Pre-analytical within seven days of screening in a clinical trial that may affect the metabolism of udenafil: |
| - Antibacterials (for example erythromycin) | |
| - Antifungals (for example itraconazole, ketoconazole) | |
| - Antivirals (for example ritonavir, saquinavir, amprenavir, indinavir, nelfinavir) | |
| - Cimetidine | |
| - Grapefruit juice | |
| 17 | Allergy or sensitivity with PDE-5 inhibitors |
CCTA; Coronary CT angiography, CMR; Cardiac magnetic resonance image, GERD; Gastroesophageal reflux disorder, LVEF; Left ventricular ejection fraction, MVA; Microvascular angina, NO; Nitric oxide, PDE-5; Phosphodiesterase-5.