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. 2014 Aug 25;14:611. doi: 10.1186/1471-2407-14-611

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© Sun et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MDM2 is a downstream target of miR-181b. A: The mRNA level of MDM2 in miR-181b overexpressed U87 cells was reduced. The protein levels of total MDM2 and phospho-MDM2 were all reduced in miR-181b overexpressed cells compared with vector control (p < 0.01). B. MiR-181b could bind to the 3’-UTR region of MDM2 (3491 to 3497), while the binding was interrupted with mutated MDM2. C: Dural luciferase reporter assay confirmed that miR-181b mimic binds to the 3’-UTR region of wild type MDM2 but not to the mutated form (p < 0.05).

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