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Downregulation of MDM2 promotes cell sensitivity to teniposide. A: The mRNA (p < 0.01) and phosphate protein level of MDM2 were all reduced after transient transfection of siRNAs in U87 cells. B: The IC50 of U87 cells to teniposide dropped from 5.86 ± 0.36 μg/ml to 2.90 ± 0.35 μg/ml upon the knockdown of MDM2.
