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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Antivir Ther. 2009;14(7):953–964. doi: 10.3851/IMP1419

Figure 3. Overlapping sites of integrase inhibitor resistance and HLA-restricted T-cell selection.

Figure 3

Map of integrase inhibitor resistance-associated sites and overlapping known (solid line) and predicted (dashed line) human leukocyte antigen (HLA)-restricted CD8+ T-cell epitopes are indicated with horizontal lines above the amino acid sequences. Known epitopes have been sourced from the Los Alamos National Laboratory HIV Immunology database and predicted epitopes are based on the Epi-pred prediction programme [35]. All amino acids are indicated by single-letter code. Highly conserved motives, the HHCC motif (coordinates zinc-binding), the DDE motif, the N-terminal domain (amino acids 1–50), the catalytic core domain (amino acids 51–212) and the C-terminal domain (amino acids 213–288) are indicated.