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. 2014 Jul 29;124(10):1622–1625. doi: 10.1182/blood-2014-05-574863

Figure 1.

Figure 1

Progressive lymphocytopenia in XLF-deficient mice. (A) Representative flow cytometric analysis of B cells in the spleen of XLF−/− mice and XLF+/+ littermates. Absolute number of mature B220+IgM+ B cells (B) and CD4+CD8− T cells (C) in the spleen of XLF−/− mice and XLF+/+ littermates; P < 2 × 10−7. (D) Representative flow cytometric analysis of B cells in the BM in XLF−/− mice and XLF+/+ littermates. (E) Percentage of total B220+ B cells in the BM of XLF−/− mice and XLF+/+ littermates; P = 1.4 × 10−7. n ≥ 3 per age group per genotype. Data represent mean ± standard deviation in all graphs. The P values in this figure were calculated by comparing the slope of regression lines between XLF+/+ and XLF−/− mice with Student t test. IgM, immunoglobulin M.