Table 1.
Incidence of metachronous cancer after successful Helicobacter pylori eradication
| Ref. | Country | Subject No. | Study design | Mean follow-up periods | Incidence (%) | Eradication effect (95%CI) |
| Uemura et al[62], 1997 | Japan | 65/67 | NR | 3 yr | 0 vs 9 | effective P = 0.011 |
| Fukase et al[14], 2008 | Japan | 272/272 | Multicenter open-label RCT | 3 yr | 3.3 vs 8.8 | effective 0.35 (0.16-0.78) P = 0.009 |
| Shiotani et al[12], 2008 | Japan | 80 | single arm | 33 mo | 11.3 | |
| Hanaoka et al[66], 2010 | Japan | 82 | 55 mo | 14.6 | ||
| Maehata et al[63], 2012 | Japan | 177/91 | retro NR | 3 yr 1.1-11.1 yr | 8.5 vs 14.3 | OR = 1.71 (0.72-4.03) |
| Kato et al[64], 2013 | Japan | 263/105 | Multicenter retro cohort | 26.8 mo 2-5 yr | 3.5/Y | NS |
| Seo et al[65], 2013 | South Korea | 61/13 | retro cohort | 27.2 mo | 9.8 vs 23.1 | OR = 0.36 (0.08-1.70), |
| Chon et al[69], 2013 | South Korea | 129 85/44 | Retro NR | 26 mo 16.5-30 mo | 4.7 vs 11.4 | effective HR = 0.143 P = 0.008 |
Subject No.: Number of subjects with eradication/without eradication and with failure of eradication; RCT: Randomized controlled trial; NR: Non-randomized; Retro: retrospective; NS: Not significant.