Table 3.

Summary of main effects and two-factor interaction statistics for alanine aminotransferase and gamma-glutamyltransferase

	Men		Women
	ALT	GGT	ALT	GGT
Main effects
Ethanol	< 0.050	< 0.001	< 0.001	< 0.001
BMI	< 0.001	< 0.001	< 0.001	< 0.001
Age	< 0.001	< 0.001	NS	< 0.001
Smoking	NS	< 0.001	NS	< 0.001
Coffee	NS	NS	NS	< 0.050
Two-factor interaction
Ethanol × age	0.008	0.001	0.295	0.197
Ethanol × BMI	0.301	0.038	0.537	0.048
Ethanol × smoking	0.398	0.094	0.794	0.001
Ethanol × coffee	0.534	0.260	0.138	0.001
BMI × age	0.003	0.067	0.502	0.788
BMI × smoking	0.878	0.342	0.904	0.690
BMI × coffee	0.430	0.653	0.261	0.090
Age × smoking	0.831	0.089	0.558	0.342
Age × coffee	0.095	0.117	0.018	0.061

The analyses of main effects and two-factor interactions were carried out using ANOVA on SPSS 21.0 for Windows statistical software. Alcohol use, BMI, smoking and coffee consumption were used as covariates, as appropriate. NS: Not significant; LT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; BMI: Body mass index.