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. 2014 Aug 21;14:28. doi: 10.1186/1471-2342-14-28

Table 4.

Simulation—smoothing kernel FWHM: mean values and (standard deviation)

Method\kernel FWHM 1 2 4 mm
Noise – No smoothing
51.7 (25.1)
49.9 (25.9)
50.0 (24.0)
Simple smoothing
64.6 (4.1)
66.4 (1.6)
60.4 (0.6)
Removed smoothing
35.7 (3.6)
33.6 (1.3)
39.6 (0.5)
Masked smoothing 50.2 (5.1) 50.0 (2.0) 50.0 (0.7)

Only the Masked Smoothing method had mean values close to the true underlying value of 50. Standard deviation values decreased as the kernel size increased.