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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: AIDS. 2012 Apr 24;26(7):805–814. doi: 10.1097/QAD.0b013e328351f780

Figure 2. Phenotype and functional characteristics of CD4+CX3CR1+ T cells.

Figure 2

(A) Flow cytometric analysis of CD27 and CD45RA (middle) and of HLA-DR (right) co-expression on resting CD4+CX3CR1+ (top) and CD4+CX3CR1− T cells (bottom) from a representative subject. (B) Positive statistical correlation in both groups (HIV− and HIV+ subjects) between the expression of CX3CR1 and the lack of expression of CD27 and CD45RA (top) and the expression of HLA-DR (bottom) on CD4+ T cells. (C) Flow cytometric analysis of TNFα and IFNγ production after TCR stimulation (using CD3/CD28 stimulation) of CD4+ T cells (left), CD4+CX3CR1− T cells (middle), and CD4+CX3CR1+ T cells (right) from a representative subject. CX3CR1 expression was defined as per the histogram on the upper right, with an unstimulated (US) control in the panel to the upper left. (D) Mean production of TNFα (top) and IFNγ (bottom) by CD4+CX3CR1+ T cells and CD4+CX3CR1− T cells upon polyclonal stimulation, as analyzed in 12 subjects.