Table 3.
Basic adjusted association between first-degree family history of hematological malignancy and lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia risk*
| Family member malignancy type and relationship to case/control† | Cases, No.‡ | Controls, No.‡ | OR (95% CI)§ | P |
|---|---|---|---|---|
| Any hematological malignancy | ||||
| No | 177 | 7303 | Referent | .050 |
| Yes | 21 | 452 | 1.65 (1.03 to 2.65) | |
| Hodgkin lymphoma | ||||
| No | 166 | 6496 | Referent | .369 |
| Yes | 2 | 34 | 2.10 (0.48 to 9.10) | |
| Non-Hodgkin lymphoma | ||||
| No | 172 | 6837 | Referent | .683 |
| Yes | 6 | 197 | 1.20 (0.52 to 2.76) | |
| Leukemia|| | ||||
| No | 165 | 6819 | Referent | .018 |
| Yes | 13 | 215 | 2.19 (1.21 to 3.96) | |
| Multiple myeloma | ||||
| No | 168 | 6496 | Referent | .143 |
| Yes | 0 | 34 | - | |
* CI = confidence interval; OR = odds ratio.
† Self-reported family history; some participants had more than one affected relative.
‡ The counts do not add up to the total number of cases/controls due to data missing by design or report.
§ Adjusted for age, sex, race/ethnicity, and study.
|| Leukemia includes chronic lymphocytic leukemia/small lymphocytic lymphoma.