Table 5.
Risk of mantle cell lymphoma associated with lifestyle factors*
| Controls, No. (%)† | Cases, No. (%)† | OR (95% CI) | P | |
|---|---|---|---|---|
| Usual adult BMI, kg/m2 | ||||
| 15–<18.5 | 197 (1.5) | 4 (0.7) | 0.87 (0.31 to 2.44) | |
| 18.5–<22.5 | 2348 (18.0) | 70 (13.1) | 1.00 (referent) | .993 |
| 22.5–<25 | 3024 (23.1) | 123 (23.0) | 1.03 (0.76 to 1.40) | |
| 25–<30 | 4755 (36.4) | 228 (42.6) | 1.03 (0.78 to 1.37) | |
| 30–<35 | 1564 (12.0) | 66 (12.3) | 0.95 (0.67 to 1.36) | |
| 35–50 | 582 (4.5) | 24 (4.5) | 1.05 (0.65 to 1.71) | |
| Usual adult weight, kg‡ | ||||
| Quartile 1 (low) | 2775 (21.2) | 103 (19.3) | 1.00 (referent) | .565 |
| Quartile 2 | 2713 (20.8) | 99 (18.5) | 0.85 (0.64 to 1.14) | |
| Quartile 3 | 3391 (25.9) | 150 (28.0) | 1.02 (0.78 to 1.32) | |
| Quartile 4 (high) | 3591 (27.5) | 163 (30.5) | 0.98 (0.76 to 1.28) | |
| Usual adult height, cm‡ | ||||
| Quartile 1 (low) | 3090 (23.6) | 120 (22.4) | 1.00 (referent) | .292 |
| Quartile 2 | 3044 (23.3) | 107 (20.0) | 0.90 (0.68 to 1.18) | |
| Quartile 3 | 3134 (24.0) | 149 (27.9) | 1.12 (0.86 to 1.44) | |
| Quartile 4 (high) | 3202 (24.5) | 139 (26.0) | 1.12 (0.86 to 1.46) | |
| History of cigarette smoking§ | ||||
| No | 5463 (42.3) | 183 (36.1) | 1.00 (referent) | .598 |
| Yes | 6531 (50.5) | 273 (53.8) | 1.06 (0.87 to 1.29) | |
| Frequency of cigarette smoking | ||||
| Nonsmoker | 5463 (42.3) | 183 (36.1) | 1.00 (referent) | .489 |
| Smoker, 1–10 cigarettes/d | 2458 (19.0) | 88 (17.4) | 1.00 (0.77 to 1.30) | |
| Smoker, 11–20 cigarettes/d | 2647 (20.5) | 127 (25.0) | 1.17 (0.92 to 1.48) | |
| Smoker, 21–30 cigarettes/d | 622 (4.8) | 28 (5.5) | 1.14 (0.75 to 1.74) | |
| Smoker, >30 cigarettes/d | 573 (4.4) | 21 (4.1) | 0.75 (0.47 to 1.20) | |
| Smoker, cigarettes/d unknown | 231 (1.8) | 9 (1.8) | 0.98 (0.49 to 1.96) | |
| History of alcohol consumption | ||||
| Nondrinker | 2121 (17.3) | 62 (12.8) | 1.00 (referent) | .965 |
| Drinker (at least 1 drink per month) | 5717 (46.8) | 221 (45.6) | 0.99 (0.72 to 1.36) | |
| Servings of alcohol per week as an adult | ||||
| Nondrinker | 2121 (17.3) | 62 (12.8) | 1.00 (referent) | .226 |
| <1 drink/wk | 815 (6.7) | 18 (3.7) | 0.6 (0.35 to 1.04) | |
| 1–6 drinks/wk | 2181 (17.8) | 85 (17.5) | 1.03 (0.72 to 1.47) | |
| 7–13 drinks/wk | 1109 (9.1) | 53 (10.9) | 1.21 (0.81 to 1.82) | |
| 14–27 drinks/wk | 947 (7.7) | 45 (9.3) | 1.14 (0.74 to 1.75) | |
| 28+ drinks/wk or binge drinkers | 636 (5.2) | 20 (4.1) | 0.92 (0.53 to 1.61) | |
| Drinker, drinks/wk unknown | 29 (0.2) | 0 (0.0) | — | |
| Total sun exposure (h/wk)† | ||||
| Quartile 1 (low) | 1508 (18.7) | 44 (16.1) | 1.00 (referent) | .428 |
| Quartile 2 | 1594 (19.8) | 42 (15.3) | 0.79 (0.51 to 1.22) | |
| Quartile 3 | 1633 (20.3) | 44 (16.1) | 0.73 (0.47 to 1.13) | |
| Quartile 4 (high) | 1714 (21.3) | 55 (20.1) | 0.72 (0.47 to 1.09) | |
| Recreational sun exposure (h/wk)† | ||||
| Quartile 1 (low) | 2234 (20.6) | 93 (22.2) | 1.00 (referent) | .133 |
| Quartile 2 | 2332 (21.6) | 85 (20.3) | 0.92 (0.69 to 1.27) | |
| Quartile 3 | 2159 (20.0) | 89 (21.3) | 0.98 (0.73 to 1.34) | |
| Quartile 4 (high) | 2983 (27.6) | 103 (24.6) | 0.74 (0.55 to 0.99) | |
| Ever used hair dyes (women only) | ||||
| Never | 856 (13.5) | 15 (6.7) | 1.00 (referent) | .517 |
| Ever | 2412 (38.1) | 53 (23.7) | 1.21 (0.67 to 2.19) | |
| Frequency of hair dye use (women only) | ||||
| Never | 856 (13.5) | 15 (6.7) | 1.00 (referent) | .507 |
| 1–5 times/y | 835 (13.2) | 13 (5.8) | 0.94 (0.43 to 2.03) | |
| 6–11 times/y | 849 (13.4) | 19 (8.5) | 1.12 (0.55 to 2.25) | |
| 12+ times/y | 507 (8.0) | 16 (7.1) | 1.77 (0.86 to 3.65) | |
| Ever, frequency unknown | 221 (3.5) | 5 (2.2) | 1.13 (0.37 to 3.49) | |
| Number of children (women only) | ||||
| 0 | 663 (7.7) | 11 (3.7) | 0.79 (0.33 to 1.86) | |
| 1 | 467 (5.5) | 11 (3.7) | 1.00 (referent) | .820 |
| 2 | 1137 (13.3) | 28 (9.4) | 0.86 (0.42 to 1.75) | |
| 3+ | 1541 (18) | 28 (9.4) | 0.61 (0.29 to 1.26) | |
| Use of oral contraceptives (women only) | ||||
| Never | 1871 (32) | 39 (20.4) | 1.00 (referent) | .805 |
| Ever | 1012 (17.3) | 18 (9.4) | 0.91 (0.45 to 1.85) | |
| Use of hormone replacement therapy (women only) | ||||
| Never | 1411 (31.2) | 25 (15.2) | 1.00 (referent) | .313 |
| Ever | 729 (16.1) | 22 (13.4) | 1.39 (0.74 to 2.62) | |
* Odds ratio (OR) and 95% confidence interval (CI) adjusted for age, sex, race, and study. BMI = body mass index.
† The counts do not always add up to the total number of cases and controls due to data missing by design or report.
‡ For height and weight, quartiles were sex-specific, based on the full control population (height, males: <172.0, 172.0–177.7, 177.8–181.9, ≥182.0cm; females: <159.0, 159.0–162.9, 163.0–167.9, ≥168.0cm; weight, males: <72.6, 72.6–79.9, 80.0–88.9, ≥89.0kg; females: <58.1, 58.1–64.9, 65.0–74.7, ≥74.8kg). For total and recreational sun exposure, study-specific quartiles are available upon request.
§ Smoked longer than 6 mo or more than 100 cigarettes in lifetime.