Table 3.
Associations between medical history and risk of Mycosis fungoides and Sézary syndrome*
| Controls | Cases | OR (95% CI)† | |
|---|---|---|---|
| No. (%) | No. (%) | ||
| Blood transfusion | |||
| No | 9591 (82.2) | 159 (78.7) | 1.00 (referent) |
| Yes | 1715 (14.7) | 34 (16.8) | 1.19 (0.81 to 1.74) |
| Ever used OC | |||
| No | 2164 (28.0) | 32 (21.6) | 1.00 (referent) |
| Yes | 1392 (18.0) | 34 (23.0) | 1.65 (0.91 to 3.01) |
| Male | 4044 (52.3) | 80 (54.1) | |
| Ever used HRT | |||
| No | 1716 (26.7) | 37 (29.6) | 1.00 (referent) |
| Yes | 1072 (16.7) | 22 (17.6) | 1.17 (0.65 to 2.13) |
| Male | 3351 (52.2) | 64 (51.2) | |
| Infection of HCV | |||
| No | 6746 (66.8) | 128 (73.6) | 1.00 (referent) |
| Yes | 152 (1.5) | 1 (0.6) | 0.47 (0.07 to 3.47) |
| Missing | 3194 (31.6) | 45 (25.9) | |
| Ulcer | |||
| No | 11639 (82.8) | 240 (86.3) | 1.00 (referent) |
| Yes | 1020 (7.3) | 17 (6.1) | 0.93 (0.56 to 1.54) |
| Psoriasis | |||
| No | 10756 (97.4) | 158 (95.8) | 1.00 (referent) |
| Yes | 256 (2.3) | 7 (4.2) | 1.94 (0.89 to 4.23) |
| Inflammatory bowel disorder | |||
| No | 14454 (97.5) | 276 (95.2) | 1.00 (referent) |
| Yes | 179 (1.2) | 7 (2.4) | 1.82 (0.83 to 3.99) |
| Ulcerative colitis | |||
| No | 11886 (97.2) | 238 (95.2) | 1.00 (referent) |
| Yes | 145 (1.2) | 5 (2.0) | 1.68 (0.67 to 4.21) |
| History of autoimmune disease | |||
| No autoimmune disease | 16500 (95.8) | 305 (94.1) | 1.00 (referent) |
| B-cell activation | 127 (0.7) | 2 (0.6) | 1.02 (0.25 to 4.17) |
| T-cell activation | 577 (3.4) | 15 (4.6) | 1.49 (0.87 to 2.55) |
| Both | 13 (0.1) | 2 (0.6) | 9.82 (2.05 to 47.03) |
| Any atopic disorder‡ | |||
| No | 11285 (65.5) | 185 (57.1) | 1.00 (referent) |
| Yes | 5690 (33.0) | 129 (39.8) | 1.25 (0.98 to 1.61) |
| Allergy§ | |||
| No | 9254 (68.8) | 161 (61.7) | 1.00 (referent) |
| Yes | 3338 (24.8) | 73 (28.0) | 0.91 (0.67 to 1.24) |
| Food allergy | |||
| No | 11065 (82.2) | 178 (68.2) | 1.00 (referent) |
| Yes | 972 (7.2) | 21 (8.0) | 1.04 (0.64 to 1.69) |
| Asthma | |||
| No | 14140 (82.8) | 260 (80.7) | 1.00 (referent) |
| Yes | 1441 (8.4) | 28 (8.7) | 0.99 (0.67 to 1.48) |
| Hay fever | |||
| No | 9198 (64.9) | 132 (48.4) | 1.00 (referent) |
| Yes | 2740 (19.3) | 55 (20.1) | 0.90 (0.63 to 1.30) |
| History of eczema | |||
| No or <2 y before diagnosis | 12157 (84.9) | 205 (74.5) | 1.00 (referent) |
| Yes, 2–<5 y before diagnosis | 74 (0.5) | 5 (1.8) | 4.12 (1.54 to 11.04) |
| Yes, 5–<10 y before diagnosis | 92 (0.6) | 7 (2.5) | 4.87 (2.15 to 11.02) |
| Yes, 10 y or more before diagnosis | 894 (6.2) | 30 (10.9) | 1.90 (1.27 to 2.85) |
| Yes, unknown age | 343 (2.4) | 10 (3.6) | 2.04 (1.03 to 4.04) |
| Missing | 751 (5.2) | 18 (6.5) | |
| First degree family history | |||
| Any hematologic malignancy | |||
| No | 10152 (76.1) | 202 (72.4) | 1.00 (referent) |
| Yes | 581 (4.4) | 16 (5.7) | 1.16 (0.68 to 1.98) |
| Multiple myeloma | |||
| No | 7671 (74.5) | 162 (71.1) | 1.00 (referent) |
| Yes | 36 (0.3) | 6 (2.6) | 6.17 (2.39 to 15.91) |
* CI = confidence interval; HCV = hepatitis C virus; HRT = hormone replacement therapy; OC = oral contraceptives; OR = odds ratio.
† OR (95% CI) adjusted for age, sex, and race.
‡ Atopic disorders include asthma, eczema, hay fever, or other allergies, excluding drug allergies.
§ History of allergy excludes drug allergies, asthma, eczema, and hay fever.