Table 1.
Systemic characteristics, single-kidney haemodynamics, and function in study groups (n = 7 each) at 16 weeks
| Parameter | Normal + Vehicle | NORMAL + Bendavia | ARVD + Vehicle | ARVD + Bendavia |
|---|---|---|---|---|
| Degree of stenosis (%) | 0 | 0 | 89.8 ± 5.2* | 81.0 ± 5.3* |
| Body weight (kg) | 51.8 ± 3.6 | 49.8 ± 8.2 | 55.8 ± 1.8 | 58.4 ± 6.3 |
| Mean blood pressure (mmHg) | 82.2 ± 41.6 | 84.4 ± 23.7 | 122.7 ± 8.9* | 123.4 ± 4.4* |
| Serum creatinine (mg/dL) | 1.5 ± 0.2 | 1.5 ± 0.1 | 1.9 ± 0.3* | 1.7 ± 0.3 |
| Plasma renin activity (ng/mL/h) | 0.16 ± 0.08 | 0.13 ± 0.11 | 0.16 ± 0.11 | 0.19 ± 0.08 |
| Isoprostane (pg/mL) | 120.4 ± 12.3 | 112.7 ± 14.9 | 201.2 ± 40.6* | 194.4 ± 30.2* |
| Total cholesterol (mg/dL) | 92.5 ± 20.6 | 84.8 ± 6.9 | 487.3 ± 53.9* | 563.0 ± 97.0* |
| HDL cholesterol (mg/dL) | 42.8 ± 16.3 | 48.2 ± 6.4 | 180.4 ± 58.6* | 196.8 ± 47.1* |
| LDL cholesterol (mg/dL) | 48.2 ± 11.0 | 34.8 ± 6.3 | 305.2 ± 77.9* | 384.5 ± 142.1* |
| Triglycerides (mg/dL) | 8.0 ± 2.4 | 9.2 ± 3.8 | 9.6 ± 8.5 | 5.8 ± 2.8 |
| Renal volume (cm3) | 102.9 ± 4.0 | 96.1 ± 6.3 | 66.4 ± 6.3*,† | 104.9 ± 3.3 |
| Cortical perfusion (mL/min/cm3) | 4.5 ± 0.5 | 4.0 ± 0.3 | 3.1 ± 0.2*,† | 4.4 ± 0.2 |
| Medullary perfusion (mL/min/cm3) | 3.0 ± 0.3 | 2.5 ± 0.6 | 1.3 ± 0.3*,† | 2.9 ± 0.4 |
| RBF (mL/min) | 553.8 ± 82.8 | 589.7 ± 71.8 | 318.8 ± 61.0*,† | 535.1 ± 24.9 |
| GFR (mL/min) | 84.0 ± 3.8 | 75.8 ± 6.8 | 48.0 ± 4.0*,† | 86.6 ± 11.2 |
| ΔRBF acetylcholine (mL/min) | 178.4 ± 63.2 | 184.5 ± 60.7 | 33.1 ± 11.2*,† | 92.0 ± 14.0 |
| ΔGFR acetylcholine (mL/min) | 20.7 ± 2.3 | 17.1 ± 2.2 | 5.4 ± 2.6*,† | 13.7 ± 3.5 |
ARVD, atherosclerotic renovascular disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein; RBF, renal blood flow; GFR, glomerular filtration rate.
*P ≤ 0.05 vs. Normal + Vehicle.
†P ≤ 0.05 vs. ARVD + Bendavia.