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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jul 30;24(17):4084–4089. doi: 10.1016/j.bmcl.2014.07.063

Scheme 2a.

Scheme 2a

aReagents and conditions: (a) H2, Pd/C, MeOH, rt, 3 h; (b) Appropriate (bromomethyl)pyridinium bromide, K2CO3, DMF, 60°C, 4 h; (c) LiOH, H2O, MeOH, THF, rt, 2 h; (d) Appropriate dibromoalkane, DMF, 60°C, 4 h; (e) Appropriate phenol, K2CO3, DMF, 60°C, 4 h;