Table 1.
Cmpd | R | R1 | R2 | TbrPDEB1 (%)a | TbrPDEB1 IC50b(µM) |
---|---|---|---|---|---|
1 | COOH | H | 16 ± 6.65 | ||
5a | COOCH3 | H | 31 ± 8 | ||
5b | COOCH3 | H | 40 ± 14 | ||
8a | H | COOH | 9.3 ± 9.3 | ||
8b | H | COOH | 20 ± 4.3 | ||
6a | H | COOCH3 | 26 ± 3.6 | ||
6b | H | COOCH3 | 28 ± 8.9 | ||
7 | COOH | H | 77 ± 6.4 | 12 ± 1.18 |
Inhibitor concentration 10.0 µM, tested in at least two independent replicate experiments all error was within 15%.
Tested in at least two independent replicate experiments.