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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jul 30;24(17):4084–4089. doi: 10.1016/j.bmcl.2014.07.063

Table 1.

Cilomilast analogs tested against TbrPDEB1

graphic file with name nihms618234t1.jpg
Cmpd R R1 R2 TbrPDEB1 (%)a TbrPDEB1 IC50b(µM)
1 graphic file with name nihms618234t2.jpg COOH H 16 ± 6.65
5a graphic file with name nihms618234t3.jpg COOCH3 H 31 ± 8
5b graphic file with name nihms618234t4.jpg COOCH3 H 40 ± 14
8a graphic file with name nihms618234t5.jpg H COOH 9.3 ± 9.3
8b graphic file with name nihms618234t6.jpg H COOH 20 ± 4.3
6a graphic file with name nihms618234t7.jpg H COOCH3 26 ± 3.6
6b graphic file with name nihms618234t8.jpg H COOCH3 28 ± 8.9
7 graphic file with name nihms618234t9.jpg COOH H 77 ± 6.4 12 ± 1.18
a

Inhibitor concentration 10.0 µM, tested in at least two independent replicate experiments all error was within 15%.

b

Tested in at least two independent replicate experiments.