TABLE I.
CLINICOPATHOLOGICAL FEATURES OF CRC CASES
| All1 | MSS+MSI-L1 | MSI-H1 | Odds ratio | p | |
|---|---|---|---|---|---|
| Number of patients | 51 | 29(57)2 | 22(43)2 | ||
| Mean age | 68 | 67 | 69 | >.53 | |
| Gender | |||||
| (M) | 22(43) | 15(52) | 7(32) | >.16 | |
| (F) | 29(57) | 14(58) | 15(68) | 2.3 | |
| Site | 49 | 29 | 20 | <.07 | |
| Proximal | 29(59) | 14(48) | 15(75) | 3.2 | |
| Distal | 20(41) | 15(52) | 5(25) | ||
| Mucin production | 51 | 29 | 22 | <.023 | |
| None | 35(69) | 24(82) | 11(50) | ||
| <50% | 5(10) | 1(3) | 4(18) | ||
| >50% | 11(21) | 4(14) | 7(32) | 4.8 | |
| Differentiation | 51 | 29 | 22 | >.74 | |
| Well | 2(4) | 1(3) | 1(5) | ||
| Moderate | 38(74) | 23(80) | 15(68) | ||
| Poor | 11(22) | 5(17) | 6(27) | ||
| Stage | 51 | 29 | 22 | >.65 | |
| I | 1(2) | 1(4) | 0(0) | ||
| II | 20(39) | 10(40) | 10(45.5) | ||
| III | 24(47) | 14(56) | 10(45.5) | ||
| IV | 6(12) | 4(15) | 2(9) | ||
| P16 methylation | 47 | 26 | 21 | >.37 | |
| (MSP) | |||||
| Methylated | 19(40) | 12(46) | 7(33) | 1.7 | |
| Unmethylated | 28(60) | 14(54) | 14(67) | ||
| hMLH1 methylation | 34 | 19 | 15 | >.99 | |
| (MSP) | |||||
| Methylated | 29(85) | 16(84) | 13(87) | .76 | |
| Unmethylated | 5(15) | 3(16) | 2(13) | ||
| hMLH1 expression by IHC | 34 | 19 | 15 | >.51 | |
| Normal | 15(44) | 10(53) | 5(33) | ||
| Partial loss | 16(47) | 8(42) | 8(53) | ||
| Complete loss | 3(9) | 1(5) | 2(13) | ||
| hMSH2 expression by IHC | 31 | 18 | 13 | ||
| Normal | 18(58) | 10(55) | 8(62) | >.99 | |
| Partial loss | 12(39) | 7(39) | 5(38) | ||
| Complete loss | 1(3) | 1(6) | 0(0) |
1
Parentheses indicate percentages: based on column values.
2
Indicates percentages based on row values.
3
Indicates a statistically significant difference in comparison of MSI-H and MSS subjects with respect to mucin production <50%.