Figure 4.
Platelets adhere to the RGD motif presented as part of an extended cadherin 6 (Cdh6) sequence. Platelets from healthy human donors (A) and wild-type mice (B) adhered to glass slides coated with a peptide corresponding to Cdh6 amino acids 73–95, containing the Cdh6 RGD motif. Mutating the RGD to RGE abrogated platelet adhesion. RGD indicates arginine-glycine-aspartic acid.